Sustaining metal-loving plants in mining regions.

www.sciencemag.org SCIENCE VOL 337 7 SEPTEMBER 2012 1141 COVER Artist’s conception of the complex network of relationships between disease and the human genome. Hundreds of diseases and traits (represented by colored dots) have been mapped to specifi c chromosomal positions in the genome. Most disease-associated genetic variants fall outside of protein-coding genes, instead affecting the genome’s regulatory circuitry by modifying the DNA “switches” (some of which are depicted here as gray triangles, many others not shown) that control gene activity. See page 1190.